合成肽的英文怎么说呢_合成肽的英文怎么说...
Synthesis of Peptides Peptides are short chains of amino acids that play important roles in various biological processes. They can act as hormones, neurotransmitters, enzymes, and structural components of proteins. The synthesis of peptides is a crucial step in the production of many drugs, including antibiotics, antivirals, and anticancer agents. In this article, we will discuss the methods used for synthesizing peptides. There are two main approaches to peptide synthesis: solid-phase synthesis and solution-phase synthesis. Solid-phase synthesis involves attaching the first amino acid to a solid support, such as a resin, and then adding subsequent amino acids one by one. This method allows for the synthesis of peptides with high purity and yields, and it is widely used in the pharmaceutical industry. Solution-phase synthesis, on the other hand, involves dissolving the amino acids in a solvent and then coupling them together. This method is less efficient than solid-phase synthesis, but it is useful for synthesizing large peptides or peptides with complex structures. The first step in peptide synthesis is the protection of the amino group and the carboxyl group of the amino acids. This is necessary because the amino group and the carboxyl group can react with each other to form a cyclic structure, which would prevent the formation of the peptide bond. The protection groups are usually removable under mild conditions, allowing for the deprotection of the amino and carboxyl groups after the peptide synthesis is complete. 您可能还想了解: 爱情童话故事短篇睡前故事 神话故事盘古开天地的故事 绘本故事《下雪了》 The next step is the activation of the carboxyl group of the amino acid. This is typically done by using a coupling reagent, such as N,N'-dicyclohexylcarbodiimide (DCC) or 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC), which reacts with the carboxyl group to form an activated ester. The activated ester then reacts with the amino group of the next amino acid, forming a peptide bond. After each coupling reaction, the peptide must be washed and purified to remove any unreacted amino acids or reagents. This is typically done by using chromatography, such as reverse-phase high-performance liquid chromatography (RP-HPLC), which separates the peptides based on their hydrophobicity. The purity of the peptide can be determined by analytical HPLC or mass spectrometry. The final step in peptide synthesis is the removal of the protection groups. This is typically done by using a reagent that selectively removes the protection group without affecting the peptide bond. Common deprotection reagents include trifluoroacetic acid (TFA) and hydrogen fluoride (HF). After deprotection, the peptide is purified again to remove any remaining impurities. In conclusion, the synthesis of peptides is a complex process that requires careful planning and execution. The choice of synthesis method, the selection of amino acids and protection groups, and the purification and characterization of the final product all play important roles in the success of peptide synthesis. With advances in technology and methodology, the synthesis of peptides has become more efficient and cost-effective, making it an important tool in drug discovery and development. |
精彩散文图文
神明保佑谢豫川涂婳小说免费阅读无弹窗_小说完结版神明保佑谢豫川涂婳 -
完本热门小说斩钉截铁聂远云韵_斩钉截铁(聂远云韵)热门小说在线阅读 -
我变成了光(秦宇林凡)免费小说阅读_完本小说免费阅读我变成了光(秦宇林凡) -
布衣官场小说苏榆北全文免费阅读苏榆北向伊雯小说推荐完结_小说免费阅读无弹窗布衣官场小说苏榆北全文免费阅读苏榆北向伊雯 -
校园:觉醒系统007她逆天改命(叶舒周盛)免费阅读完整版小说_免费热门小说校园:觉醒系统007她逆天改命叶舒周盛 -
暴君太病娇,炮灰公主逃不掉江无眠耶律央免费小说全本阅读_免费阅读无弹窗暴君太病娇,炮灰公主逃不掉(江无眠耶律央) -
七零娇娇驭夫指南(苏酥江云飞)免费阅读完整版小说_热门小说阅读七零娇娇驭夫指南(苏酥江云飞) -
带百亿物资穿越成农家小福宝(苏沐瑶苏三郎)小说最新章节_完结小说免费阅读带百亿物资穿越成农家小福宝苏沐瑶苏三郎 -